Key Highlights
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Researchers found that changes in brain volume on MRI scans are only weakly and inconsistently linked to actual worsening of disability in people with primary progressive multiple sclerosis over two years. This finding questions the common practice of using brain shrinkage as a primary measure of success in clinical trials for this disease.
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A new blood test for a protein called p-tau217 has been thoroughly validated and shown to be highly accurate and reliable for detecting Alzheimer’s disease, paving the way for its use in routine clinical care. This simple blood test could help doctors diagnose Alzheimer’s more easily and earlier than with current methods like spinal taps.
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A new study in rodents shows that nonnutritive sweeteners, often used as a control in research, may actually influence the brain’s reward system and alter how sugar appetite is studied, potentially leading to misleading results. This review suggests that scientists must be very careful using these sweeteners in experiments about sugar addiction and craving.
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