How Chromatin Remodellers Read DNA: A Mechanistic Breakthrough
A Journal Club piece in Nature Reviews Genetics highlights a landmark 2021 study by Donovan et al. that finally unpacks the long-standing puzzle of how chromatin remodelling complexes achieve sequence-specific targeting. Beyond the well-known correlation between remodeller localization and transcription factor binding, this work reveals a direct, mechanistic link: remodellers can recognize and bind specific DNA sequences through their own intrinsic domains, independent of co-factors. By dissecting the structural basis of this recognition, the authors provide a framework for understanding how these molecular machines are precisely guided to their genomic destinations—a question that has implications for gene regulation, development, and the maintenance of cellular identity.
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