Key Highlights
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A new review reveals a strong two-way relationship between the body’s energy molecule NAD+ and the internal circadian clock in dementia, showing this interaction influences sleep and memory loss. This discovery suggests that targeting this pathway with strategies like NAD+ precursors, timed light exposure, and exercise could lead to new treatments for dementia.
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A compound found in olive oil, Hydroxytyrosol, was shown to reduce anxiety-like behavior after a traumatic experience in aged mice by boosting the growth of new brain cells in the hippocampus and protecting healthy gut bacteria. This points to a simple, dietary-based approach to potentially increase resilience to stress and post-traumatic stress disorder (PTSD) in older adults.
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Researchers discovered that the diabetes drug Vildagliptin protects brain cells in a mouse model of Parkinson’s disease by calming a key inflammatory pathway (NLRP3 inflammasome) and activating a cell survival pathway (PI3K/AKT). This finding highlights a potential new way to repurpose an existing diabetes medication to slow the progression of Parkinson’s disease.
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