Key Highlights
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A new study on caffeine’s effects in rats found that the brain’s α1-adrenergic receptor is involved in how the drug is perceived and how it creates taste aversions. This helps explain the complex ways caffeine interacts with the brain and could inform research on substance use and addiction.
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UK experts have released new safety-focused guidelines for using the Alzheimer’s drug lecanemab, specifying it’s for patients with mild symptoms who have confirmed amyloid brain plaques and are not carriers of two copies of the APOE4 gene. These recommendations aim to ensure the drug is used safely and effectively in clinical practice, marking a significant step in managing Alzheimer’s disease.
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Research from a long-term Finnish study found that a smaller left hippocampus and more white matter damage around the brain’s ventricles, as seen on MRI scans, are linked to a higher risk of becoming frail in the future. This suggests that brain health scans could one day help identify older adults at risk for physical decline, even before symptoms appear.
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