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Medicine · Neurology

Researchers have developed a novel, scalable method to isolate functional growth cone particles and immature synaptosomes from human cerebral organoids using differential centrifugation. The protocol captures distinct developmental stages at Day 90 and 150, validated through quantitative proteomics, electron microscopy, and KCl-induced depolarization assays. This advancement provides a clinically relevant platform for studying synaptic maturation in neurodevelopmental and neurodegenerative disorders, directly supporting evidence-based investigations into disease mechanisms and potential therapeutic targets.

Novelty: 87%

Rigor: 92%

Significance: 85%

Validity: 90%

Clarity: 88%

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