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Home - Neurology - El sueño fragmentado: un acelerador molecular para la patología amiloide

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El sueño fragmentado: un acelerador molecular para la patología amiloide

Last updated: April 2, 2026 9:15 pm
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El sueño fragmentado: un acelerador molecular para la patología amiloide

Un estudio longitudinal con más de 1200 participantes del Alzheimer’s Disease Neuroimaging Initiative (ADNI) ha investigado la conexión entre la alteración del sueño y la dinámica del amiloide beta (Aβ) en líquido cefalorraquídeo (LCR). Los hallazgos revelan que la alteración del sueño basal se asocia con una tasa más rápida de disminución longitudinal de los niveles de Aβ42 en el LCR, sugiriendo que la falta de sueño podría acelerar directamente la acumulación de esta proteína patológica. Para profundizar en los mecanismos, los investigadores integraron datos de proteómica del LCR con análisis de redes de co-expresión génica…

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