The Molecular Link Between Sleepless Nights and Alzheimer’s Progression
A new longitudinal study of over 1,200 participants from the Alzheimer’s Disease Neuroimaging Initiative provides robust clinical evidence linking sleep disturbance to the acceleration of amyloid beta pathology. The analysis found that baseline sleep disturbance was associated with a faster rate of longitudinal decline in cerebrospinal fluid Aβ42 levels. To identify the molecular mechanisms underlying this association, researchers integrated CSF proteomics with weighted gene co-expression network analysis…
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