Key Highlights
•
A 12-month follow-up of the DISTAL trial found that endovascular treatment plus best medical treatment did not reduce disability or death compared to best medical treatment alone for patients with medium or distal vessel occlusion stroke. These results confirm that routine endovascular treatment is not supported for patients with mild-to-moderate strokes of this type.
Source →
•
A new study shows that a protein kinase CK2 inhibitor, CX-4945, significantly reduces kidney damage in mouse models of lupus by modulating neutrophil infiltration and NET formation. This identifies CK2 as a novel therapeutic target and supports repurposing the drug for lupus and other inflammatory autoimmune diseases.
Source →
•
An AI-powered cloud platform (US2.AI) showed high agreement with expert clinicians in measuring 10 key echocardiographic parameters from pre-operative scans, including left ventricular function and valve disease. This supports integrating AI into peri-operative workflows to streamline point-of-care echocardiography for anesthesiologists.
Source →
•
Researchers developed a digital seed amplification assay (dSAA) that can precisely quantify TDP-43 protein aggregates in cerebrospinal fluid, with elevated levels found in patients with frontotemporal dementia. This new diagnostic tool offers potential for earlier and more accurate diagnosis of dementia subtypes driven by misfolded proteins.
Source →
•
The Copenhagen City Heart Study established age- and sex-specific normal values for left ventricular strain rates in nearly 2,000 healthy individuals, finding that a low late diastolic strain rate independently predicted heart failure, cardiovascular death, and heart attack. This provides a new clinical tool for early detection of heart risk using standard echocardiography.
Source →
Stay curious. Stay informed —
Science Briefing
