Key Highlights
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A study on former elite rugby players found they have distinct changes in blood proteins related to brain health, including lower levels of a protein called KLK6. This suggests that repetitive head impacts from contact sports may alter brain biology long before any dementia symptoms appear, potentially offering a way to identify at-risk individuals earlier.
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Researchers discovered that a single episode of acute stress can impair a mouse’s ability to adapt to changing rules, a cognitive skill known as reversal learning. This happens because stress alters both brain chemistry and gene activity in a specific region called the orbitofrontal cortex, which is crucial for flexible decision-making.
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A study in people with moderate to advanced dementia with Lewy bodies (DLB) shows that cognitive fluctuations—where mental clarity varies throughout the day—are linked to a greater burden of neuropsychiatric symptoms like depression and anxiety. This connection significantly worsens patients’ quality of life, highlighting the need for treatments that specifically target these fluctuating symptoms.
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