Key Highlights
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A new type of CAR T-cell therapy targeting a protein called uPAR can eliminate solid tumors in mice by attacking both the cancer cells and the surrounding supportive tissue. This approach, when combined with drugs that induce cellular aging (senescence), successfully treated primary and spreading tumors with minimal damage to the bone marrow, offering a promising new strategy for cancers that are typically hard to treat with immunotherapy.
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Shiga toxin, produced by harmful E. coli bacteria, helps the pathogen take over the gut by speeding up how quickly food moves through the intestines, which flushes out helpful resident microbes. This creates space for the invading bacteria to grow, revealing a previously unknown way the toxin benefits the bug’s survival inside a host, beyond just making people sick.
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Scientists have found a way to block a specific cellular enzyme (CBLB) with a small molecule, which stops the tagging and subsequent removal of the Epidermal Growth Factor Receptor (EGFR) from the cell surface. This inhibition reduces the receptor’s internalization and weakens the signals that drive cell movement, pointing to a potential new method for controlling processes involved in cancer metastasis and wound healing.
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