Key Highlights
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Researchers found that a drug originally designed for measles, ERDRP-0519, can also block the Nipah virus, though it works less effectively against it. By studying the structure of the viral polymerases, the team identified why this difference exists and used that knowledge to design new, more potent inhibitors against Nipah virus, a deadly pathogen with pandemic potential.
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Scientists discovered that a protein called LRBA is essential for helping the kidneys manage water and salt balance, acting like a traffic controller for tiny cellular packages in kidney cells. This finding explains why patients with LRBA deficiencies face severe dehydration risks, offering a new target for treating kidney-related fluid and electrolyte disorders.
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A new AI tool called eSIG-Net has been developed as an “interaction language model” that can predict how a single mutation in a protein will affect its ability to interact with other proteins. This breakthrough allows scientists to rapidly decode the effects of genetic changes, accelerating drug discovery and our understanding of diseases caused by protein malfunctions.
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