Key Highlights
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A new method called in-vivo cross-linking mass spectrometry (XL-MS) can capture weak and temporary protein interactions inside living cells, which are often missed by traditional techniques. This is crucial for drug discovery because it helps map the complex networks of how proteins work together in their natural environment, revealing targets for new medicines.
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Researchers have developed a new way to measure how accurately lab-grown human intestinal cells mimic real human tissue, using a biomedical foundation model. This provides a powerful tool to improve the quality of cell cultures used for testing drugs and studying diseases, making experiments more reliable and predictive of what happens in the human body.
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Structures inside the cell nucleus called nuclear speckles are specialized for processing a specific type of genetic message with a balanced structure of coding and non-coding segments. Their evolution helped shape the overall organization of genomes in animals like reptiles, birds, and mammals, revealing a fundamental link between cellular architecture and genetic information.
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