Key Highlights
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A new study reveals that during nutrient shortages, inflammatory cytokines can activate a protein called ZBTB5, which in turn switches on the mTORC1 signaling pathway in tumor cells. This activation helps the cancer cells take up more amino acids, which fuels their growth and helps them resist anti-cancer immunotherapy.
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Researchers have discovered a new function for a lesser-known variant of the famous p53 tumor suppressor gene, called p53psi. This finding is significant because it shows that this specific variant plays important roles in normal development and in preventing tumors, helping us understand the full complexity of the body’s cancer defense system.
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Scientists are championing new, human-centered methods for discovering drugs, such as using lab-grown mini-organs (organoids) and computer simulations. This shift promises to make drug development faster, more accurate, and more ethical by reducing reliance on animal testing and better mimicking human biology.
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