Key Highlights
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Scientists have solved the structure of a protein complex (RPGR and TTLL5) that is essential for healthy vision, revealing how mutations in these proteins cause retinal diseases like retinitis pigmentosa. This discovery provides a clear molecular target for developing new therapies to treat these forms of blindness.
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An oral antiviral drug, 4′-fluorouridine, has shown significant promise in treating lethal Nipah virus infection in a hamster model, reducing mortality and disease severity. This represents a crucial step toward the first effective oral treatment for this high-threat pandemic virus.
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A new software toolkit called CREsted can now model how DNA enhancers control cell-specific gene activity using large-scale genetic data. This tool helps decode the genomic “instruction manual” that determines cell identity and function, accelerating research in development and disease.
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Soil microbes can adapt their heat tolerance in response to warming, a process that reduces predicted soil carbon dioxide emissions by 36%. This finding reveals a critical biological buffer against climate change that must be included in future climate models.
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