Key Highlights
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A new method called “Optovolution” uses light and the yeast cell cycle to rapidly evolve proteins that can be controlled by light, like switches or logic gates. This breakthrough makes it possible to engineer complex, light-responsive proteins for biotechnology and medicine that were previously very difficult to create.
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Different animal species have evolved unique ways to stabilize the unstable microtubule structures that are essential for dividing up the contents of a fertilized egg. This discovery explains how early embryos across the tree of life reliably create the right compartments for development to proceed.
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In pancreatic cancer cells driven by the MYC gene, a nutrient-sensing protein called MondoA is crucial because it helps coordinate the cancer’s growth signals with its cellular stress response. This finding reveals a new vulnerability in aggressive cancers that could be targeted for therapy.
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A comprehensive assessment shows that Oxford Nanopore’s long-read sequencing technology is now highly accurate for detecting most types of genetic variants, making it ready for use in clinical diagnostics. This is a major step towards using this faster, more portable technology to diagnose genetic diseases in hospitals.
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Researchers have released an updated computational tool, TLSEA 2.0, which helps scientists understand the function of long non-coding RNAs by identifying other biological processes they are linked to. This tool is vital for deciphering the roles of these mysterious RNA molecules in health and disease.
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