The Immune System’s Role in Mania: A New Proteomic Window
A new proof-of-concept study uses high-resolution platelet proteomics to investigate the biological underpinnings of mania in bipolar disorder. Researchers analyzed platelet samples from hospitalized patients with severe mania and matched healthy controls, revealing a distinct proteomic signature. The findings indicate that mania is associated with a significant downregulation of proteins, with the most robust alterations converging on immune-related pathways.
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