The Brain’s Internal Chaos: How a Tiny Fraction of Neurons Governs Mood and Variability
A new computational study reveals how a sparse population of fast-spiking interneurons (FSIs)—making up just 1% of the striatum—exerts outsized control over neural variability and correlation. This network, characterized by highly shared feedforward inhibition, does more than synchronize activity; it fundamentally shapes how the brain’s reward and motor circuits respond to cortical inputs. The research shows that increased sharing of this inhibition amplifies the across-trial variability in the responses of medium spiny neurons (MSNs), the striatum’s principal cells. Furthermore, the FSI network acts as a dynamic filter, capable of bidirectionally modulating correlations…
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