Key Highlights
•
Among 5,325 in-hospital cardiac arrests with a shockable rhythm, survival fell from 73% after one defibrillation to 41% after four attempts, but then plateaued at 24% by nine attempts. This suggests current resuscitation strategies may not effectively terminate shockable rhythms, highlighting a need for novel therapeutic approaches.
Source →
•
The enhanced liver fibrosis (ELF) test and liver stiffness measurement (LSM) were used to screen 972 at-risk patients in Leeds. While 72% of patients from alcohol services had low ELF scores (<9.5), 31% of those who underwent LSM showed readings ≥15 kPa, indicating advanced fibrosis and supporting targeted screening for early diagnosis of steatotic liver disease.
Source →
•
A population pharmacokinetic/pharmacodynamic model using 5,918 plasma samples from 743 patients established MTX concentration thresholds for nephrotoxicity risk in primary central nervous system lymphoma treatment: 9.71, 0.81, and 0.26 μmol/L at 24, 48, and 72 hours. This provides a practical tool for early identification and monitoring of methotrexate-induced renal injury.
Source →
Stay curious. Stay informed —
Science Briefing
