Atherogenic Index and Glucose Disposal Rate Predict Cardiovascular Risk in CKM Syndrome
Key Highlights
Medicine · Diabetes
A 9-year nationwide prospective cohort study examined the joint association of the atherogenic index of plasma (AIP) and estimated glucose disposal rate (eGDR) with new-onset cardiovascular disease risk in individuals with cardiovascular–kidney–metabolic (CKM) syndrome stages 0–3. The researchers found that a higher AIP combined with a lower eGDR was significantly associated with an increased risk of developing cardiovascular disease, suggesting a synergistic effect of dyslipidemia and insulin resistance. For a leading diabetologist focused on clinical management and complications, this finding provides a practical, dual-biomarker approach to stratify cardiovascular risk in patients with early-stage CKM syndrome, a common comorbidity in diabetes care in India.
Novelty: 82%
Rigor: 90%
Significance: 88%
Validity: 87%
Clarity: 92%
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