Key Highlights
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A recent national shortage of a nasal spray for a hormone deficiency forced patients to switch to a pill form, but over half of those switched using a common dose ratio experienced a return of symptoms like excessive thirst and urination. This highlights the need for personalized dosing and better guidance when drug supplies are disrupted, as the switch created a significant burden for patients and clinics.
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A study found that in pregnancies with gestational diabetes, the baby’s pancreas is larger and appears brighter on ultrasound as early as the second trimester, which may reflect the baby’s response to the mother’s high blood sugar. This suggests that scanning the fetal pancreas could be a useful early marker for gestational diabetes, potentially aiding in earlier detection and monitoring.
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A new review explains that diagnosing Cushing’s syndrome, a condition caused by too much cortisol, is difficult because its symptoms are common and current tests often miss the body’s natural daily cortisol rhythm. The authors argue that measuring and restoring this daily rhythm could be a better way to diagnose and monitor the condition, especially in milder cases.
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A large study of over 73,000 patients found that being underweight or having severe obesity increases the risk of not being able to live independently after surgery, while being overweight or having mild obesity was linked to a lower risk. This “U-shaped” relationship challenges simple assumptions about weight and surgical recovery, suggesting that a moderate amount of body fat might be protective for regaining independence.
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