Building Trust: A Framework for Sustainable Community Partnerships in Clinical Research
A new perspective in Clinical Pharmacology & Therapeutics addresses the chronic challenge of variable health outcomes driven by imbalanced participation in clinical research. The authors argue that novel therapeutics based on narrow cohorts limit validity and generalizability, and that bridging the representation gap requires novel approaches, particularly in communities with historical mistrust of medical institutions. Drawing on a nearly two-decade-long partnership with an Indigenous community in Montana, the authors present a framework of community-engaged strategies designed to build meaningful, enduring research partnerships.
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