A new frontier in the HIV reservoir: Mapping the viral sanctuaries
A recent study has employed advanced single-cell genomic sequencing to map the precise cellular and anatomical niches that harbor latent HIV-1 provirus in individuals on long-term antiretroviral therapy. This high-resolution analysis reveals a previously underappreciated heterogeneity in the viral reservoir, identifying specific subsets of CD4+ T cells with distinct transcriptional profiles that serve as preferential sanctuaries for viral persistence.
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