A New Frontier in HIV Persistence: Unmasking the Latent Reservoir
A recent study published in Nature Immunology provides a critical advance in understanding the cellular mechanisms that allow HIV to persist despite antiretroviral therapy. The research identifies a novel subset of CD4+ T cells with a distinct metabolic and epigenetic profile that acts as a preferential sanctuary for the latent virus. This discovery challenges previous models of viral latency and suggests that the reservoir is not randomly distributed but is actively maintained within a specific immunological niche.
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