Key Highlights
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This study from the LEGACY cohort found that pregnant women with lupus who were exposed to azathioprine had a significantly higher risk of developing intrahepatic cholestasis of pregnancy (ICP), with 17.4% of exposed women developing the condition compared to 2.5% of unexposed women. The research highlights a potential link between azathioprine use and a serious pregnancy complication, underscoring the need for careful monitoring in this vulnerable population.
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This scoping review examined 33 studies and found that language barriers in paediatric emergency care pose significant safety risks at multiple stages, with the discharge process being the most frequently reported point of vulnerability. The findings emphasize that improving communication through professional interpreter services and exploring new technologies like artificial intelligence could help mitigate these risks and improve patient safety.
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This study found that integrating polygenic risk scores (PRS) and transcriptional risk scores (TRS) from blood samples significantly improved Alzheimer’s disease detection, achieving better classification performance than using PRS alone. The combined model offers a non-invasive and cost-effective approach to early diagnosis across diverse populations, which is particularly relevant for identifying cognitive decline in patients with conditions like diabetes.
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Science Briefing
