Key Highlights
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Researchers found that deleting a gene called Six3 from specific brain cells that regulate the body’s daily clock shortened the internal circadian rhythm in mice. This suggests Six3 plays a unique role in fine-tuning our biological clock’s timing, separate from its close relative Six6, which had no such effect.
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A new scoring system was created to measure the burden of small vessel disease, a type of blood vessel damage in the brain, from large national autopsy data. This standardized tool directly links higher levels of this vascular damage to worse cognitive function and a greater likelihood of dementia, helping to clarify its role in age-related memory loss.
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A clinical trial showed that using personalized brain scans (fMRI) to guide transcranial magnetic stimulation (TMS) to a specific threat-processing circuit can effectively treat symptoms of PTSD. This targeted approach represents a significant advance over standard, non-personalized brain stimulation, offering a more precise potential treatment for trauma-related disorders.
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