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Home - Public Health - The Real-World Shield: How Well the Flu Vaccine Protects Children

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The Real-World Shield: How Well the Flu Vaccine Protects Children

Last updated: April 7, 2026 3:07 pm
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The Real-World Shield: How Well the Flu Vaccine Protects Children

A large, multi-season study from the New Vaccine Surveillance Network provides crucial real-world evidence on pediatric influenza vaccine effectiveness (VE). Analyzing data from seven US pediatric medical centers across three seasons (2021–2024), researchers tracked over 19,000 children with acute respiratory illness to determine how well vaccination prevented influenza-associated hospitalizations and outpatient visits. The study found that overall vaccine effectiveness varied significantly by season, with the lowest protection observed in the 2021–2022 period.

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