A New Era of Precision: Photoswitchable Ligands for GPCRs
A new review in Trends in Pharmacological Sciences explores the frontier of photoswitchable ligands for G-protein-coupled receptors (GPCRs). These are molecules whose biological activity can be toggled on and off with precise pulses of light, offering unprecedented spatial and temporal control over receptor signaling. The concept of “allosteric” and “dualsteric” photoswitchable ligands represents a significant leap in pharmacological tool design, allowing researchers to dissect complex GPCR signaling pathways with a level of precision previously unattainable.
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