A new scaffold emerges: Phthalazinone-imidazoline hybrids target elusive kinases
Recent research presents a novel class of hybrid molecules, ingeniously fusing the phthalazinone and imidazoline pharmacophores. This rational design strategy aims to overcome the selectivity and pharmacokinetic challenges often associated with targeting specific kinase families in oncology. Preliminary in vitro data indicate that these compounds exhibit a unique binding mode…
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