A new frontier in HIV persistence
Recent research has identified a novel cellular reservoir that may be responsible for the persistence of HIV-1 despite effective antiretroviral therapy. The study, employing advanced single-cell sequencing and spatial transcriptomics, reveals a subset of myeloid cells in lymphoid tissues that harbor transcriptionally silent but replication-competent provirus. This discovery challenges the long-held focus on CD4+ T cells as the primary sanctuary for the latent virus and suggests a more complex…
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