Key Highlights
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A study of patients with severe mania found their blood platelets showed signs of immune system activation and deficits in a key pathway (MHC Class I) that helps cells present antigens. This suggests that immune system irregularities and possibly chronic, low-level inflammation could play a role in the biology of bipolar disorder.
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Researchers warn that a common method used to measure if a patient’s condition has meaningfully improved with treatment does not reliably identify who is actually responding to the therapy. This is a crucial distinction for clinical trials, as it means a general change score may not pinpoint the individuals who truly benefit from a new drug.
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A randomized study found that the antidepressant effects of ketamine in people with major depression involve specific changes in blood flow within the brain that are modulated by the body’s opioid system. This helps explain how ketamine works and could guide the development of safer, more targeted treatments for depression.
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