Key Highlights
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Researchers have identified a harmful stress response inside mitochondria, driven by a protein called PGAM5, as a common feature in amyotrophic lateral sclerosis (ALS). Targeting PGAM5 reduces this stress and improves disease pathology across different ALS subtypes, offering a promising new therapeutic strategy.
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Scientists have deconstructed a fear memory in the brain, identifying distinct groups of neurons that were active during specific moments of learning. They also pinpointed the core “engram” of cells essential for forming the memory itself, providing a clearer picture of how the brain encodes experiences.
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Using a high-tech light-based brain scanner on monkeys, researchers showed that the brain functionally rewires connections between motor areas to recover hand dexterity after a stroke. This demonstrates that the technology can effectively monitor the brain’s reorganization during rehabilitation, offering a new tool for tracking recovery.
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A new study challenges the idea that immune cells simply squeeze through tissues without gripping them, showing they actually use intermittent, grip-like forces when navigating tight 3D spaces. This finding revises our understanding of how immune cells patrol the body and could inform new approaches to treating inflammation and disease.
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Scientists have discovered that a key protein, Atg2, acts like a bridge to transfer lipids from the cell’s internal warehouse (the endoplasmic reticulum) to the forming “autophagosome,” a structure that cleans up cellular waste. This process is reversible, highlighting a sophisticated system for managing the cell’s building blocks and maintaining balance during cleanup.
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