The latest discoveries in Endocrinology
A concise briefing on the most relevant research developments in your field, curated for clarity and impact.
The body’s internal clock: a master regulator of metabolic disease
This commentary outlines how the combined forces of circadian biology and sleep homeostasis govern the timing of metabolic and endocrine functions. It argues that a misalignment between these internal rhythms and external behaviors—such as that caused by shift work, jet lag, or insufficient sleep—acts as a powerful driver for obesity, insulin resistance, and broader cardiometabolic disease.
Why it might matter to you:
Understanding the circadian drivers of metabolic dysfunction provides a foundational mechanism linking environmental and lifestyle factors to systemic disease. This perspective is critical for research into how metabolic disturbances, such as those seen in obesity, can create a permissive environment for other pathologies, including cancer. It positions circadian misalignment as a modifiable risk factor with implications for both preventive strategies and therapeutic timing.
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