Immune Dysregulation: A New Proteomic Window into Mania
A new proof-of-concept study published in *Psychiatry and Clinical Neurosciences* has used high-resolution platelet proteomics to uncover a distinct signature of immune dysregulation in patients with severe mania. Researchers performed liquid chromatography–tandem mass spectrometry on platelet samples from hospitalized manic patients and matched healthy controls, revealing that mania is associated with a proteomic profile rich in immune activation signals but deficient in proteins related to cellular homeostasis. The analysis identified a prominent cluster of downregulated proteins, with the most robust alterations pointing to deficits in MHC Class I-mediated antigen processing pathways.
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