A landmark review reframes the hallmarks of cancer for a new era
In a seminal review published in *Cell*, Douglas Hanahan revisits and expands the influential “hallmarks of cancer” framework, synthesizing 25 years of conceptual refinement. The article presents a multidimensional view of tumor biology, integrating not only the core aberrant capabilities of cancer cells but also enabling traits, the complex roles of the tumor microenvironment, and systemic interactions. It proposes that a mechanism-guided approach, co-targeting multiple hallmarks, could unlock promising new therapeutic strategies. This work provides a critical, updated roadmap for understanding the converging biological forces that drive tumorigenesis.
Why it might matter to you:
This authoritative synthesis directly informs the strategic direction of cancer cell biology research, offering a coherent framework to prioritize investigations into oncogenes, tumor suppressors, and cellular senescence. For professionals focused on the molecular underpinnings of cancer, it provides a critical lens to evaluate new findings in signaling pathways like PI3K/AKT and mTOR within a broader, systems-level context. The emphasis on co-targeting hallmarks could influence the design of next-generation high-content screening and preclinical studies using organoids.
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