Personalized briefing
Discovery of the day · Neurology
[Articles] Antiseizure medication use in pregnancy and the risk of poor fetal growth in the EURAP international registry: a prospective cohort study
Dear Kelly M Leyden, this is your personalized scientific intelligence briefing — curated for your work in Neurology.
Key finding
Medicine · Neurology
Discovery of the day
This prospective cohort study from the EURAP international registry demonstrates that exposure to antiseizure medications in utero is associated with a significantly increased risk of poor fetal growth, an adverse outcome that must now be considered alongside the known risks of congenital malformations and neurodevelopmental effects. The researchers found that the risk of poor fetal growth varies substantially across individual antiseizure monotherapies and specific drug combinations, and it escalates with the number of concomitant antiseizure medications taken during pregnancy. These findings provide critical data for risk stratification and individualised treatment selection during preconception counselling, directly informing clinical decisions for women with epilepsy.
Novelty
72%
Rigor
88%
Significance
84%
Validity
81%
Clarity
90%
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