HRT Timing and Duration May Reduce LATE-NC Risk in Older Women
Personalized briefing
Discovery of the day · Neurology
Hormone replacement therapy and its association with LATE‐NC in older adults
Dear Kelly M Leyden, this is your personalized scientific intelligence briefing — curated for your work in Neurology.
Key finding
Medicine · Neurology
Discovery of the day
This study demonstrates that hormone replacement therapy (HRT) is associated with reduced odds of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC), a common dementia mimic of Alzheimer’s disease, in older adults. In a cohort of 2,056 participants from the Religious Orders Study and Memory and Aging Project, researchers found that HRT use within 5 years before or after menopause (OR=0.70) or for 8 to 16 years (OR=0.44) was significantly associated with lower odds of LATE-NC at autopsy. These findings underscore the critical importance of HRT timing and duration as potential modifiable factors in dementia risk, providing a clinically actionable insight for therapeutic decision-making in postmenopausal women that may complement blood-based proteomic and imaging biomarkers in neurodegenerative disease assessment.
Novelty
86%
Rigor
88%
Significance
92%
Validity
78%
Clarity
84%
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