Cortical Microstructural MRI Changes Precede Amyloid Positivity in Alzheimer’s Disease
Key Highlights
Medicine · Neurology
A large cross-sectional study of 1,323 non-demented older adults has revealed that microstructural cortical changes detectable by MRI, particularly reduced gray–white matter contrast (GWC), precede amyloid-β (Aβ) positivity and macrostructural atrophy in Alzheimer’s disease. The researchers found that GWC and mean diffusivity (MD) showed stronger associations with age than traditional measures like volume and thickness, and that these microstructural markers exhibited minimal overlap with macrostructural changes. This finding is particularly relevant to your work in preclinical models at the Brain and Mind Centre, as it suggests that MRI-based microstructural markers could serve as earlier in vivo indicators of Alzheimer’s pathology, potentially enabling intervention during a stage where novel therapeutic strategies—including those targeting pain and neuroinflammation—might be most effective.
Novelty: 83%
Rigor: 91%
Significance: 88%
Validity: 87%
Clarity: 90%
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