Porous Media Framework of Intracellular Diffusion Extended Beyond Inert Molecules
Key Highlights
Biology · Cell Biology
This correspondence, published in the Proceedings of the National Academy of Sciences, extends the porous media framework of intracellular diffusion beyond inert molecules. The authors provide a compelling argument that this physical model can describe the movement of biologically active macromolecules within the crowded cellular environment. For a researcher interested in cellular and tissular disruptions, this work offers a fundamental advance in understanding how diffusive constraints within the cytoplasm can impact the availability and localization of molecules involved in key signaling and stress-response pathways, including those relevant to apoptosis, autophagy, and aging.
Novelty: 88%
Rigor: 85%
Significance: 82%
Validity: 90%
Clarity: 91%
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