Key Highlights
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Researchers found that plasma p-tau181, an Alzheimer’s biomarker, is elevated in patients with amyotrophic lateral sclerosis (ALS) and increases over a year, while another marker, NfL, remains stable. This suggests p-tau181 provides a complementary biological signal in ALS, reflecting peripheral processes distinct from disease progression measured by NfL.
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A new study shows that combining a polygenic risk score with a blood-based transcriptional risk score significantly improves the early detection of Alzheimer’s disease across diverse populations. The integrated model achieved better classification accuracy than using genetic information alone, offering a non-invasive, accessible screening approach.
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A study in mice shows that the drug L-NAME can either increase or decrease the effects of sleep loss on behavior, depending on the context of chronic stress. This finding highlights the complex neurobiology underlying the interaction between stress, sleep, and brain function.
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