Key Highlights
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Researchers have found that a protein called Folate receptor beta (FRβ) plays a surprising new role in the immune system, acting as a master switch that turns on a powerful inflammatory process known as the NLRP3 inflammasome in macrophages—key immune cells.
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This discovery reveals that FRβ works independently of its known job of transporting folate (a vitamin), instead controlling inflammation by regulating DNA methylation and potassium flow in cells. This opens up a potential new target for therapies aimed at dampening harmful inflammation in diseases like autoimmunity and cancer.
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