Key Highlights
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A simple blood test measuring the ratio of neutrophils to lymphocytes (NLR) is linked to a higher future risk of Alzheimer’s disease and related dementias. This finding, from two large healthcare databases, suggests that systemic inflammation, which this ratio reflects, plays a key role in the development of neurodegenerative diseases.
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Researchers have found that the complement system, a part of the immune system, contributes to hyperactive behavior in a mouse model of a genetic condition linked to autism and developmental disorders. This discovery points to immune dysfunction as a potential driver of behavioral symptoms in neurodevelopmental conditions, opening new avenues for treatment.
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A large-scale brain imaging study of people with PTSD found altered connections between the amygdala and hippocampus, brain regions critical for emotion and memory. This provides a biological explanation for the emotional and memory disturbances seen in PTSD and could help in developing more targeted therapies.
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