Mapping the Brain’s Cellular Universe: A New Atlas Integrates Form and Function
A new, high-resolution three-dimensional atlas provides a quantitative map of cell type densities across the entire mouse brain, integrating transcriptomic, morphological, and electrophysiological data for the first time. This resource addresses a critical gap in neuroscience by scaling regional density estimates from brain slices and applying voxel-wise corrections in dense areas like the cerebellum. To link genetic identity to functional properties, the researchers leveraged patch-sequencing datasets from cortical neurons, assigning transcriptomic, morphological, and electrophysiological types through a combination of gene expression analysis, structural reconstruction, and clustering algorithms.
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