The Molecular Mechanics of a Failing Heart
A new study in Biophysical Journal investigates how genetic mutations that cause cardiomyopathy alter the fundamental mechanics of the human cardiac muscle protein myosin. The research focuses on a critical step in the force-generation cycle known as the recovery stroke, where myosin repositions its active site for ATP hydrolysis and interaction with actin. Using advanced computational methods, the team modeled how specific disease-causing mutations remodel the free-energy landscape of this conformational change.
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