The Heart’s Molecular Mechanics: How Mutations Disrupt the Cardiac Engine
The precise choreography of the human heart muscle relies on the myosin protein, which converts chemical energy from ATP into mechanical force. A new biophysical study investigates how genetic mutations linked to cardiomyopathy alter the critical “recovery stroke” of human cardiac β-myosin. This conformational change is essential for positioning the protein’s active site for ATP hydrolysis and subsequent interaction with actin filaments. The research employs free-energy calculations to model how specific mutations remodel the energy landscape of this fundamental step…
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