The Molecular Engine of the Heart: How Mutations Rewire Cardiac Muscle Mechanics
A new study in Biophysical Journal investigates how genetic mutations linked to cardiomyopathy alter the fundamental mechanics of human cardiac β-myosin. The research focuses on the “recovery stroke,” a critical conformational change where myosin repositions its active site for ATP hydrolysis and subsequent interaction with actin filaments. Using computational free-energy analysis, the authors reveal how specific disease-causing mutations remodel the energy landscape of this essential step…
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