Key Highlights
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A large study confirms that a gene called SLC12A6, when altered, can cause Charcot-Marie-Tooth disease, a common inherited nerve disorder. This finding means that doctors should test for this specific gene in all patients suspected of having an inherited neuropathy, as it could lead to a more precise diagnosis.
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In a mouse model of Alzheimer’s, a drug that calms brain inflammation (MW151) improved sleep problems in female mice without reducing the hallmark amyloid plaques. This suggests that targeting inflammation could be a fast way to treat sleep disturbances in Alzheimer’s, which are more common in women and appear early in the disease.
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A case series reports that Alzheimer’s disease can be transmitted through rare, accidental medical exposure, leading to high levels of disease pathology in the brain. This is a crucial finding for understanding disease mechanisms and reinforces the importance of strict safety protocols in medical procedures.
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A new organoid model shows that Hepatitis E virus can infect and damage not just liver cells, but also cells in mini-brains, including neurons that produce dopamine. This reveals the virus’s potential to affect the nervous system and provides a powerful new tool for studying viral infections and testing drugs.
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An editorial highlights that while stroke death rates are falling globally, the total number of people affected is rising due to aging populations, with huge inequalities between rich and poor countries. Closing the gaps in stroke prevention and care across Europe by 2030 is an urgent public health priority to reduce this burden.
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