A Metabolic Detective Story in the Skin
Understanding how drugs are metabolized in the skin is crucial for predicting efficacy and toxicity. A new study in Chemical Research in Toxicology investigates the presence of key drug-metabolizing enzymes, including cytochrome P450s, in human keratinocytes. The research specifically focuses on the antiepileptic drug lamotrigine, probing whether these skin cells can generate reactive phenolic metabolites…
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