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Home - Emergency Medicine - A Rare Lung Mass in a Young Man: A Case of Unicentric Castleman Disease

Emergency Medicine

A Rare Lung Mass in a Young Man: A Case of Unicentric Castleman Disease

Last updated: March 17, 2026 7:26 am
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A Rare Lung Mass in a Young Man: A Case of Unicentric Castleman Disease

A recent case report details the presentation of a rare, benign tumor in an 18-year-old male who arrived with a paroxysmal cough and scant sputum production. The patient’s chest CT scan revealed a well-defined, round mass near the right middle lobe hilum, which showed significant vascular enhancement. Following thoracoscopic resection, the pathology confirmed hyaline-vascular Castleman disease, a non-cancerous lymphoproliferative disorder. This case underscores the importance of including rare entities in the differential diagnosis during the evaluation of a lung mass, particularly in younger patients presenting with respiratory symptoms. The report highlights key diagnostic imaging findings and the definitive role of histopathological examination in guiding management and ensuring a favorable long-term outcome without recurrence.

Study Significance: For emergency physicians, this case reinforces the critical need for a broad differential during the initial assessment of respiratory complaints and chest imaging findings. Recognizing atypical presentations of conditions like Castleman disease can prevent misdiagnosis and guide appropriate specialist referral for definitive management. It also illustrates the value of point-of-care ultrasound (POCUS) and advanced imaging in the acute care setting to characterize masses and plan subsequent steps in patient care.

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