Key Highlights
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A study of over 850 older transfeminine adults found they had a 39% higher odds of Alzheimer’s disease and related dementias compared to cisgender men, with the association being even stronger for those who had received gender-affirming hormone therapy. This suggests dementia diagnosis and care should be a priority in the healthcare of older transgender women, particularly those with a history of hormone therapy.
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A new review details how MRI can now be used to map the electrical conductivity of tissues, which differs at low and high frequencies and reflects tissue structure and ionic composition. This non-invasive technique has the potential to become a routine part of MRI scans, improving diagnostic accuracy and monitoring of treatments.
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An analysis of nearly 100 oral anticancer drugs found that 86% have at least one known mechanism for interacting with other medications, and among cancer patients, over 17% had a potentially dangerous overlapping prescription. This highlights the critical need for doctors and pharmacists to carefully manage these common drug interactions to ensure treatment is both safe and effective.
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In patients with systemic lupus erythematosus (SLE), a dual-targeting CAR-T cell therapy that attacks both BCMA and CD19 led to a deeper reset of the immune system than therapy targeting CD19 alone, more effectively depleting disease-causing plasma cells. This suggests a potential advantage for the dual-targeting approach in achieving better control of the autoimmune disease.
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Research using a multi-omics approach found that the common environmental pollutant TBOEP promotes fat accumulation in liver cells by dysregulating key metabolic pathways. This provides new evidence that everyday chemical exposures could be a contributing risk factor for fatty liver disease.
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