A cellular master switch for ovarian function and dysfunction
A comprehensive review in *Reproductive Biology and Endocrinology* synthesizes the critical role of the PI3K/Akt signaling pathway in the development of ovarian follicles and in non-malignant ovarian disorders. This central cellular pathway regulates key processes like cell growth, survival, and metabolism within the ovary. The article details how dysregulation of PI3K/Akt signaling is implicated in conditions such as polycystic ovary syndrome (PCOS) and primary ovarian insufficiency (POI), linking molecular disruptions to clinical manifestations of ovarian dysfunction.
Why it might matter to you:
This work provides a mechanistic framework for understanding how fundamental cellular signaling cascades govern ovarian health and aging. For researchers investigating fertility and reproductive aging, it highlights PI3K/Akt as a potential nexus where internal factors and external stressors could converge to disrupt follicular development. Targeting this pathway may offer a strategic avenue for developing interventions aimed at preserving ovarian function or mitigating age-related decline.
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